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When coupled to -arrestins, GPCRs are desensitized by abrogated coupling to G proteins and trafficked away from the cell surface, destined for either re-sensitization following their recycling back to the plasma membrane, or for final signal termination resulting from their degradation in lysosomes (McCorvy et al., 2017)
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Patients with well-managed hypothyroidism on stable levothyroxine replacement can generally proceed with GLP-1 therapy if clinically indicated
The findings identified a mechanism distinct from previously known appetite-control pathways as an avenue by which GLP-1s could treat other dysfunctions in reward processing, such as substance use disorder
Embracing ones natural skin tone can often be a healthier path
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